RESUMO
AIMS: Based on recent studies, it was indicated that gold (Au-197) nanoparticles could be safely prescribed and used to enhance the absorbed dose during radiation therapy. SUBJECTS AND METHODS: We evaluated the samarium-153 (Sm-153) radiopharmaceutical and Au-197 and Sm-153 radiopharmaceutical absorbed dose rate by means of the Monte Carlo technique in prostate cancer. RESULTS: The results show that absorbed dose rate in entire prostate volume due to 20 mCi of Sm-153 radiopharmaceutical is 27.339 µGy/s, 48.837 µGy/s, and 76.176 µGy/s for γ-interaction, ߯ particle interaction, and γ+߯ interaction, respectively. The results in the exterior of the prostate for ߯ interaction, ߯ particle interaction, and γ+߯ interaction were 20.971 µGy/s, 1.110 µGy/s, and 22.081 µGy/s, respectively. CONCLUSIONS: The calculation results for Au-197 and Sm-153 radiopharmaceutical show that the absorbed dose rate in entire prostate volume 3% was increased and undesirable dose value in exterior of prostate 7% was decreased.
Assuntos
Quimiorradioterapia/métodos , Coloide de Ouro/administração & dosagem , Modelos Biológicos , Neoplasias da Próstata/terapia , Compostos Radiofarmacêuticos/administração & dosagem , Combinação de Medicamentos , Humanos , Masculino , Nanopartículas Metálicas/administração & dosagem , Método de Monte Carlo , Próstata/efeitos dos fármacos , Próstata/efeitos da radiação , Radioisótopos/administração & dosagem , Dosagem Radioterapêutica , Samário/administração & dosagemRESUMO
OBJECTIVE: To determine the frequency of use of different types of CAM among patients who attended outpatient general practices (GP). METHODS: CAM use, type, reason, administration, satisfaction, and disclosure to physician were documented by interviewing 360 patients. RESULTS: A total of 192 individuals (53.3%) reported that they were using or had used at least one form of CAM therapy (a total of 343 CAM therapies). The five most commonly used CAM therapies were, respectively, vitamin supplements (105 subjects, 54.7%), traditional herbal products (80 cases, 41.7%), mineral supplements (58 cases, 30.2%), herbal medicines (49 cases, 25.5%) and dietary therapies (18 cases, 9.4%); 240 therapies (70%) were self-prescribed. CONCLUSION: A substantial number of the patients had used CAM on their own; one-third of these patients did not have sufficient knowledge about the therapies used. Health care providers should be aware of this practice by the patients and seek information about CAM usage.
